Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 2
1995 3
1996 2
1997 5
1998 5
1999 3
2000 5
2001 3
2002 2
2003 2
2004 4
2005 3
2006 7
2007 1
2008 1
2009 9
2010 3
2011 3
2012 2
2013 2
2014 5
2015 6
2016 6
2017 4
2018 5
2019 6
2020 5
2021 5
2022 3
2023 2
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

109 results

Results by year

Filters applied: . Clear all
Page 1
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring.
Mascharak S, desJardins-Park HE, Davitt MF, Griffin M, Borrelli MR, Moore AL, Chen K, Duoto B, Chinta M, Foster DS, Shen AH, Januszyk M, Kwon SH, Wernig G, Wan DC, Lorenz HP, Gurtner GC, Longaker MT. Mascharak S, et al. Science. 2021 Apr 23;372(6540):eaba2374. doi: 10.1126/science.aba2374. Science. 2021. PMID: 33888614 Free PMC article.
Skin scarring, the end result of adult wound healing, is detrimental to tissue form and function. Engrailed-1 lineage-positive fibroblasts (EPFs) are known to function in scarring, but Engrailed-1 lineage-negative fibroblasts (ENFs) remain poorly chara …
Skin scarring, the end result of adult wound healing, is detrimental to tissue form and function. Engrailed-1 lineage-positive …
Opposing Functions of BRD4 Isoforms in Breast Cancer.
Wu SY, Lee CF, Lai HT, Yu CT, Lee JE, Zuo H, Tsai SY, Tsai MJ, Ge K, Wan Y, Chiang CM. Wu SY, et al. Mol Cell. 2020 Jun 18;78(6):1114-1132.e10. doi: 10.1016/j.molcel.2020.04.034. Epub 2020 May 23. Mol Cell. 2020. PMID: 32446320 Free PMC article.
Bromodomain-containing protein 4 (BRD4) is a cancer therapeutic target in ongoing clinical trials disrupting primarily BRD4-regulated transcription programs. ...Through integrated RNA-seq, genome-wide ChIP-seq, and CUT&RUN association profiling, we identify the Engr …
Bromodomain-containing protein 4 (BRD4) is a cancer therapeutic target in ongoing clinical trials disrupting primarily BRD4-regulated …
Atomistic molecular dynamics simulations of bioactive engrailed 1 interference peptides (EN1-iPeps).
Gandhi NS, Blancafort P, Mancera RL. Gandhi NS, et al. Oncotarget. 2018 Apr 27;9(32):22383-22397. doi: 10.18632/oncotarget.25025. eCollection 2018 Apr 27. Oncotarget. 2018. PMID: 29854286 Free PMC article.
The neural-specific transcription factor Engrailed 1 - is overexpressed in basal-like breast tumours. Synthetic interference peptides - comprising a cell-penetrating peptide/nuclear localisation sequence and the Engrailed 1-specific sequence from the N …
The neural-specific transcription factor Engrailed 1 - is overexpressed in basal-like breast tumours. Synthetic interference p …
Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation.
Györfi AH, Matei AE, Fuchs M, Liang C, Rigau AR, Hong X, Zhu H, Luber M, Bergmann C, Dees C, Ludolph I, Horch RE, Distler O, Wang J, Bengsch B, Schett G, Kunz M, Distler JHW. Györfi AH, et al. J Exp Med. 2021 Sep 6;218(9):e20201916. doi: 10.1084/jem.20201916. Epub 2021 Jul 14. J Exp Med. 2021. PMID: 34259830 Free PMC article.
Transforming growth factor-beta (TGFbeta) is a key mediator of fibroblast activation in fibrotic diseases, including systemic sclerosis. Here we show that Engrailed 1 (EN1) is reexpressed in multiple fibroblast subpopulations in the skin of SSc patients. We c …
Transforming growth factor-beta (TGFbeta) is a key mediator of fibroblast activation in fibrotic diseases, including systemic sclerosis. Her …
Quadruple negative breast cancer.
Huang M, Wu J, Ling R, Li N. Huang M, et al. Breast Cancer. 2020 Jul;27(4):527-533. doi: 10.1007/s12282-020-01047-6. Epub 2020 Jan 14. Breast Cancer. 2020. PMID: 31939077 Review.
Different from AR-positive triple-negative breast cancer, QNBC is insensitive to conventional chemotherapeutic agents and has no efficient treatment targets. However, QNBC has been shown to express unique proteins that may be amenable to use in the development of targeted …
Different from AR-positive triple-negative breast cancer, QNBC is insensitive to conventional chemotherapeutic agents and has no efficient t …
Deletions of 2q14 that include the homeobox engrailed 1 (EN1) transcription factor are compatible with a normal phenotype.
Barber JC, Maloney VK, Bewes B, Wakeling E. Barber JC, et al. Eur J Hum Genet. 2006 Jun;14(6):739-43. doi: 10.1038/sj.ejhg.5201605. Eur J Hum Genet. 2006. PMID: 16552425
BAC FISH showed that the deletion included a minimum of 20 genes including the homeobox engrailed 1 gene (EN1). However, the same deletion was also found in his phenotypically normal father and brother (family 1). The phenotype of the proband may, ther …
BAC FISH showed that the deletion included a minimum of 20 genes including the homeobox engrailed 1 gene (EN1). …
A knock-in allele of En1 expressing dre recombinase.
Plummer NW, de Marchena J, Jensen P. Plummer NW, et al. Genesis. 2016 Aug;54(8):447-54. doi: 10.1002/dvg.22954. Epub 2016 Jul 9. Genesis. 2016. PMID: 27313055 Free PMC article.
Engrailed 1 (En1) is a homeobox-containing transcription factor expressed during development in diverse tissues, including the embryonic midbrain and anterior hindbrain. ...To avoid disrupting En1 function, the Dre cDNA is inserted at the 3' end …
Engrailed 1 (En1) is a homeobox-containing transcription factor expressed during development in diverse tissues, …
EN1 Regulates Cell Growth and Proliferation in Human Glioma Cells via Hedgehog Signaling.
Chang J, Guo C, Li J, Liang Z, Wang Y, Yu A, Liu R, Guo Y, Chen J, Huang S. Chang J, et al. Int J Mol Sci. 2022 Jan 20;23(3):1123. doi: 10.3390/ijms23031123. Int J Mol Sci. 2022. PMID: 35163043 Free PMC article.
Through cross-species transcriptome studies, we found that Engrailed 1 (EN1) is highly expressed in serum-free cultured glioma cells as well as glioma tissues, and increased expression level predicts a worse prognosis. ...It also influences sensitivity of gli …
Through cross-species transcriptome studies, we found that Engrailed 1 (EN1) is highly expressed in serum-free cultured …
Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring.
Jiang D, Correa-Gallegos D, Christ S, Stefanska A, Liu J, Ramesh P, Rajendran V, De Santis MM, Wagner DE, Rinkevich Y. Jiang D, et al. Nat Cell Biol. 2018 Apr;20(4):422-431. doi: 10.1038/s41556-018-0073-8. Epub 2018 Mar 28. Nat Cell Biol. 2018. PMID: 29593327
We show that dermal development and regeneration are driven by engrailed 1-history-naive fibroblasts, whose numbers subsequently decline. Conversely, engrailed 1-history-positive fibroblasts possess scarring abilities at this early stage and their expa …
We show that dermal development and regeneration are driven by engrailed 1-history-naive fibroblasts, whose numbers subsequent …
Postnatal signalling with homeoprotein transcription factors.
Prochiantz A, Fuchs J, Di Nardo AA. Prochiantz A, et al. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26;369(1652):20130518. doi: 10.1098/rstb.2013.0518. Philos Trans R Soc Lond B Biol Sci. 2014. PMID: 25135979 Free PMC article. Review.
In this review, we discuss their postnatal and adult physiological functions based on the study of Otx2, Engrailed-1 and Engrailed-2 (collectively Engrailed). For Engrailed, we discuss its function in the cell-autonomous regulation of ventral midbrain dopaminergic n …
In this review, we discuss their postnatal and adult physiological functions based on the study of Otx2, Engrailed-1 and Engra …
109 results